A Role of the Bile Salt Receptor FXR in Atherosclerosis

This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism. At the molecular level, bile salts regulate lipid and energy homeostasis mainly via the bile salt receptors FXR and TGR5. Activation of FXR has been shown to improve plasma lipid profiles, whereas Fxr(-/-) mice have increased plasma triglyceride and very-low-density lipoprotein levels. Nevertheless, high-density lipoprotein cholesterol levels are increased in these mice, suggesting that FXR has both anti-and proatherosclerotic properties. Interestingly, there is increasing evidence for a role of FXR in "nonclassical" bile salt target tissues, eg, vasculature and macrophages. In these tissues, FXR has been shown to influence vascular tension and regulate the unloading of cholesterol from foam cells, respectively. Recent publications have provided insight into the antiinflammatory properties of FXR in atherosclerosis. Bile salt signaling via TGR5 might regulate energy homeostasis, which could serve as an attractive target to increase energy expenditure and weight loss. Interventions aiming to increase cholesterol turnover (eg, by bile salt sequestration) significantly improve plasma lipid profiles and diminish atherosclerosis in animal models. Bile salt metabolism and bile salt signaling pathways represent attractive therapeutic targets for the treatment of atherosclerosi

Autothermal Reforming of Methane with Integrated CO2 Capture in a Novel Fluidized Bed Membrane Reactor. Part 2 Comparison of Reactor Configurations

The reactor performance of two novel fluidized bed membrane reactor configurations for hydrogen production with integrated CO2 capture by autothermal reforming of methane (experimentally investigated in Part 1) have been compared using a phenomenological reactor model over a wide range of operating conditions (temperature, pressure, H2O/CH4 ratio and membrane area). It was found that the methane combustion configuration (where part of the CH4 is combusted in situ with pure O2) largely outperforms the hydrogen combustion concept (oxidative sweeping combusting part of the permeated H2) at low H2O/CH4 ratios (<2) due to in situ steam production, but gives a slightly lower hydrogen production rate at higher H2O/CH4 ratios due to dilution with combustion products. The CO selectivity was always much lower with the methane combustion configuration. Whether the methane combustion or hydrogen combustion configuration is preferred depends strongly on the economics associated with the H2O/CH4 ratio

Accuracy of bubble velocity measurement with a four-point optical fibre probe

For the operation of high void fraction bubbly flows in bubble\ud columns, insight in primary parameters such as bubble size,\ud shape and velocity as well as gas volume fraction is essential.\ud At high gas volume fractions the flow system becomes\ud opaque, ruling out non-intrusive optical techniques. As an\ud alternative optical fibre probes can be used, which have the\ud advantage of low cost, simplicity of setup and easy\ud interpretation of the results.\ud By using four-point optical fibre probe, properties of bubbles\ud can be studied, such as bubble velocity, bubble size, etc.\ud However, the effect of bubble wobbling behaviour and\ud physical properties of liquids on the accuracy of the velocity\ud measurements has not been investigated in detail.\ud In the present study, the performance of a four-point optical\ud fibre probe was evaluated for five different liquids. The probe\ud performance and causes of inaccuracies are discuss

Semiclassical gaps in the density of states of chaotic Andreev billiards

The connection of a superconductor to a chaotic ballistic quantum dot leads to interesting phenomena, most notably the appearance of a hard gap in its excitation spectrum. Here we treat such an Andreev billiard semiclassically where the density of states is expressed in terms of the classical trajectories of electrons (and holes) that leave and return to the superconductor. We show how classical orbit correlations lead to the formation of the hard gap, as predicted by random matrix theory in the limit of negligible Ehrenfest time \tE, and how the influence of a finite \tE causes the gap to shrink. Furthermore, for intermediate \tE we predict a second gap below E=\pi\hbar /2\tE which would presumably be the clearest signature yet of \tE-effects.Comment: Refereed version. 4 pages, 3 figure

Empirical progress and truth approximation by the 'Hypothetico-Probabilistic Method'

Three related intuitions are explicated in this paper. The first is the idea that there must be some kind of probabilistic version of the HD-method, a 'Hypothetico-Probabilistic (HP-) method', in terms of something like probabilistic consequences, instead of deductive consequences. According to the second intuition, the comparative application of this method should also be functional for some probabilistic kind of empirical progress, and according to the third intuition this should be functional for something like probabilistic truth approximation. In all three cases, the guiding idea is to explicate these intuitions by explicating the crucial notions as appropriate 'concretizations' of their deductive analogs, being 'idealizations'. It turns out that the comparative version of the proposed HP-method amounts to the likelihood comparison (LC-) method applied to the cumulated evidence. This method turns out to be not only functional for probabilistic empirical progress but also for probabilistic truth approximation. The latter is based on a probabilistic threshold theorem constituting for this reason the analog of the deductive success theorem

Azimuth axis optical alignment system Final report

Azimuth axis optical alignment system to monitor and measure attitude or angular position of remote object about azimuth axis using phase information imposed on returning beam of ligh